Midbrain Dopamine Neurons Signal Belief in Choice Accuracy during a Perceptual Decision

Central to the organization of behavior is the ability to predict the values of outcomes to guide choices. The accuracy of such predictions is honed by a teaching signal that indicates how incorrect a prediction was (“reward prediction error,” RPE). In several reinforcement learning contexts, such as Pavlovian conditioning and decisions guided by reward history, this RPE signal is provided by midbrain dopamine neurons. In many situations, however, the stimuli predictive of outcomes are perceptually ambiguous. Perceptual uncertainty is known to influence choices, but it has been unclear whether or how dopamine neurons factor it into their teaching signal. To cope with uncertainty, we extended a reinforcement learning model with a belief state about the perceptually ambiguous stimulus; this model generates an estimate of the probability of choice correctness, termed decision confidence. We show that dopamine responses in monkeys performing a perceptually ambiguous decision task comply with the model’s predictions. Consequently, dopamine responses did not simply reflect a stimulus’ average expected reward value but were predictive of the trial-to-trial fluctuations in perceptual accuracy. These confidence-dependent dopamine responses emerged prior to monkeys’ choice initiation, raising the possibility that dopamine impacts impending decisions, in addition to encoding a post-decision teaching signal. Finally, by manipulating reward size, we found that dopamine neurons reflect both the upcoming reward size and the confidence in achieving it. Together, our results show that dopamine responses convey teaching signals that are also appropriate for perceptual decisions

Physiology of rat retinal pericytes: modulation of ion channel activity by serum-derived molecules

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65646/1/j.1469-7793.1999.00637.x.pd

Immunological Pathogenesis of Endolymphatic Hydrops and Its Relation to Meniere\u27s Disease

This study was designed to investigate an immunologically induced endolymphatic hydrops (ELH) and to focus on the issue of its pathogenesis in relation to Meniere\u27s disease. The time course of ELH was evaluated by light microscopy in a 2-hour to 7-month period following direct antigen challenge to the endolymphatic sac (ELS) in systemically pre-sensitized guinea pigs. ELH began to appear in the vestibule and the basal turn 5-7 hours after inner ear challenge and developed gradually. During the interval from the second day to the first week, ELH rapidly developed in all the cochlear turns and reached a maximum size. During the period from the second week to the eighth week, ELH gradually reduced. After 9 weeks, ELH of the saccule and the cochlea gradually recurred. During the interval from the first week to the eighth week, the time course of ELH correlated well with the grade of cellular infiltration of the perisaccular tissue. These results suggest that recurrent immunological reaction in the ELS may result in disorders of the ELS which finally lead to the onset of Meniere\u27s disease

The CWKB particle production and classical condensate in de Sitter spacetime

The complex time WKB approximation is an effective tool in studying particle production in curved spacetime. We use it in this work to understand the formation of classical condensate in expanding de Sitter spacetime. The CWKB leads to the emergence of thermal spectrum that depends crucially on horizons (as in de Sitter spacetime) or observer dependent horizons (as in Rindler spacetime). A connection is sought between the horizon and the formation of classical condensate. We concentrate on de Sitter spacetime and study the cosmological perturbation of $k=0$ mode with various values of $m/H_0$. We find that for a minimally coupled free scalar field for $m^2/H_0^2<2$, the one-mode occupation number grows more than unity soon after the physical wavelength of the mode crosses the Hubble radius and soon after diverges as $N(t)\sim O(1)[\lambda_{phys}(t)/{H_0^{-1}}]^{2\sqrt{\nu^2-1/4}}$, where $\nu\equiv (9/4 -m^2/{H_0^2})^{1/2}$. The results substantiates the previous works in this direction. We also find the correct oscillation and behaviour of $N(z)$ at small $z$ from a single expression using CWKB approximation for various values of $m/H_0$. We also discuss decoherence in relation to the formation of classical condensate. We also find that the squeezed state formalism and CWKB method give identical results.Comment: 19 pages, revtex, 5 figure

Application of transparent microperforated panels to acrylic partitions for desktop use: A case study by prototyping

There are various measures currently in place to prevent the spread of coronavirus (COVID-19); however, in some cases, these can have an adverse effect on the acoustic environment in buildings. For example, transparent acrylic partitions are often used in eating establishments, meeting rooms, offices, etc., to prevent droplet infection. However, acrylic partitions are acoustically reflective; therefore, reflected sounds may cause acoustic problems such as difficulties in conversation or the leakage of conversation. In this study, we performed a prototyping of transparent acrylic partitions to which a microperforated panel (MPP) was applied for sound absorption while maintaining transparency. The proposed partition is a triple-leaf acrylic partition with a single acrylic sheet without holes between two MPP sheets, as including a hole-free panel is important to prevent possible droplet penetration. The sound absorption characteristics were investigated by measuring the sound absorption in a reverberation room. As the original prototype showed sound absorption characteristics with a gentle peak and low values due to the openings on the periphery, it was modified by closing the openings on the top and sides. The sound absorption performance was improved to some extent when the top and sides were closed, although there remains the possibility of further improvement. For this study, only the sound absorption characteristics were examined in the prototype experiments. The effects during actual use will be the subject of future study

Multipartite entanglement, quantum-error-correcting codes, and entangling power of quantum evolutions

We investigate the average bipartite entanglement, over all possible divisions of a multipartite system, as a useful measure of multipartite entanglement. We expose a connection between such measures and quantum-error-correcting codes by deriving a formula relating the weight distribution of the code to the average entanglement of encoded states. Multipartite entangling power of quantum evolutions is also investigated.Comment: 13 pages, 1 figur